Progress in Neuro-Psychopharmacology & Biological Psychiatry Cannabinoid CB1 receptors in the dorsal hippocampus and prelimbic medial prefrontal cortex modulate anxiety-like behavior in rats: Additional evidence

نویسندگان

  • Sabrina F. Lisboa
  • Anna A. Borges
  • Priscila Nejo
  • Aline Fassini
  • Francisco S. Guimarães
  • Leonardo B. Resstel
چکیده

Abbreviations: ECBS, Endocannabinoids; AEA, An amide hydrolase; CB1, Cannabinoid type 1 receptor; CB2 TRPV1, Transient potential vanilloid type 1 receptor; CBD, tex; MPFC, Medial prefrontal córtex; PL, Prelimbic; HI Hippocampus; PAG, Periaqueductal gray matter; THC, Δ9 Elevated plusmaze; VCT, Vogel conflict test; AP, Anteropos ⁎ Corresponding author at: Pharmacology Departme Preto, University of São Paulo (FMRP/USP), Av Band Ribeirão Preto, São Paulo, Brazil, 14049-900. E-mail address: [email protected] (S.F. Lisboa).

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Endocannabinoid System and TRPV1 Receptors in the Dorsal Hippocampus of the Rats Modulate Anxiety-like Behaviors

Objective(s) Fatty acid is amide hydrolase which reduce endogenous anandamide. Transient receptor potential vanilloid-1 (TRPV1) channels have been reported to have a role in the modulation of anxiety-like behaviors in rodents. In the present study, the effects of either endocannabinoid system or TRPV1 channels and their possible interaction on anxiety-like behaviors of the rats were explored. ...

متن کامل

The Study of Apomorphine Effects and Heterogeneity in the Medial Prefrontal Cortex on the Dopaminergic Behaviors of Rats

Objective(s) While the nucleus accumbens and the striatum have received much attention regarding their roles in stereotyped behaviors, the role of the medial prefrontal cortex (mPFC) has not been investigated to the same degree. Few studies have reported the role of the mPFC in dopaminergic induction of locomotor hyperactivity. The mPFC is a heterogeneous area (the anterior cingulated, prelimbi...

متن کامل

Cannabinoid receptors: nomenclature and pharmacological principles.

The CB1 and CB2 cannabinoid receptors are members of the G protein-coupled receptor (GPCR) family that are pharmacologically well defined. However, the discovery of additional sites of action for endocannabinoids as well as synthetic cannabinoid compounds suggests the existence of additional cannabinoid receptors. Here we review this evidence, as well as the current nomenclature for classifying...

متن کامل

Limbic system mechanisms of stress regulation: hypothalamo-pituitary-adrenocortical axis.

Limbic dysfunction and hypothalamo-pituitary-adrenocortical (HPA) axis dysregulation are key features of affective disorders. The following review summarizes our current understanding of the relationship between limbic structures and control of ACTH and glucocorticoid release, focusing on the hippocampus, medial prefrontal cortex and amygdala. In general, the hippocampus and anterior cingulate/...

متن کامل

prelimbic of medial prefrontal cortex GABA modulation through testosterone on spatial learning and memory

Prefrontal cortex (PFC) is involved in multiple functions including attentional , spatial orientation, short and long-term memory. Our previous study indicated that microinjection of testosterone in CA1 impaired spatial learning and memory. Some evidence suggests that impairment effect of testosterone is mediated by GABAergic system. In the present study, we investigated the interaction of test...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 2015